The natural history of non-human GB virus C in captive chimpanzees
نویسندگان
چکیده
منابع مشابه
The natural history of non-human GB virus C in captive chimpanzees
GB virus C (GBV-C) is a common, non-pathogenic human virus that infects lymphocytes. Persistent GBV-C infection of humans with coexistent human immunodeficiency virus (HIV) infection is associated with prolonged survival, and GBV-C replication inhibits HIV replication in vitro. A GBV-C virus variant was identified in chimpanzees in 1998 and was named GBV-C(trog) or GBV-C(cpz). The prevalence an...
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GB virus C (GBV-C) is a nonpathogenic lymphotropic virus that replicates in B and T lymphocytes. Infection with GBV-C is documented worldwide and is common: between 1% and 5% of healthy blood donors are viremic at the time of donation. Antibodies to GBV-C proteins are not usually detected during viremia, and antibodies to the GBV-C envelope glycoprotein E2 develop following the clearance of vir...
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GB virus C quasispecies detected in plasma and lymphocyte subsets in a natural human infection.
Genomic heterogeneity and quasispecies composition of GB virus C (GBV-C) within plasma and lymphocyte subsets in a naturally infected blood donor were investigated. For this purpose, fragments from the 5' untranslated region (5' UTR) and the E2 gene recovered from plasma, B and T lymphocytes, were cloned and sequenced. A total of 63 clones was analysed: 95.2 % of them (n=60) - obtained from pla...
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Over 70% of individuals acutely infected with hepatitis C virus (HCV) develop chronic infection at significant risk of progressive liver fibrosis and subsequent liver cirrhosis and hepatocellular carcinoma. Various viral, host, and environmental factors have been reported to affect the natural history of HCV infection such as chronicity in acute phase and disease progression in chronic phase. R...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2010
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.026088-0